Effect of enteral nutrition on warfarin therapy. Appropriate timing of medication in relation to feeds may help minimise the interactions. If it is not feasible to withhold enteral feeding, drug plasma levels and patients clinical progress should be closely monitored, and consideration should be given to increase the oral dosage.
Dietary interaction with phenytoin. Difficulty with anticoagulation may still be experienced with the newer formulations. Supplemental Content Full text links. Choose courses based on your needs. Didn't get the message? Predictable reduction in anticoagulant activity of warfarin by small amounts of vitamin K.
Develop Your Own Curriculum. Some indicators[6,10] which may prompt medical staff to check for possible interaction include: The warfarin solubility was higher when enteral formula was added.
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Br J Med Protein binding and warfarin loss In vitro models have been used to study the warfarin interaction with enteral formulas because of ethical reasons and difficulty in controlling confounding factors in human participants. Better navigate the business aspects of medicine and stay on top of the changing healthcare landscape.
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Am J Hosp Pharm Cutie AJ, Altman E. Discontinuation of the Osmolite resulted in a prompt prolongation of the prothrombin time.
Some indicators[6,10] which may prompt medical staff to check for possible interaction include:. Warfarin tablet dissolution was compared to the injectable formulation, which served as a control.
Previous reports of warfarin resistance implicated older enteral feeding products with a much higher vitamin K content. Gain Essential Business Knowledge. This drug-nutrient interaction is well documented. Formulas sold as liquid meal replacement products for oral consumption are typically very similar in composition to the intact protein formulas used in these studies.
The second reported kindred with hereditary resistance to oral anticoagulant drugs.