Br J Clin Pharmacol. OBRA-specified dosages of commonly used anxiolytic and sedative-hypnotic drugs are listed in Table 5. Tricyclic and tetracyclic antidepressants.
Retrieved 20 April QT prolongation has been reported with trazodone therapy. Several post-marketing reports have been made of arrhythmia in trazodone-treated patients who have pre-existing cardiac disease and in some patients who did not have pre-existing cardiac disease. This page was last edited on 16 Octoberat Atypical antipsychotics Olanzapine Quetiapine Risperidoneetc. Early recognition of any abnormal erectile function is important, including prolonged or inappropriate erections, and should prompt discontinuation of trazodone treatment.
Trazodone also has anti-anxiety anxiolytic and sleep-inducing hypnotic effects. American Society of Consultant Pharmacists, Want to use this article elsewhere?
Prediction and Prevention of Drug Side Effects. Because trazodone has minimal anticholinergic activity, it was especially welcomed as a treatment for geriatric patients with depression when it first became available. Psychotropic Drug Treatment of Alcohol. The prescribing patterns for anxiolytic and sedative-hypnotic drugs are less consistent. J Am Geriatr Soc. Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramineetc.
However, nefazodone inhibits the cytochrome P 3A4 pathway, and it may exhibit dangerous interactions with cisapride. According to the OBRA strategy, the long-term care facility, rather than the prescribing physician, is accountable for monitoring drug use.
Journal of Clinical Psychopharmacology.
Increased cholinergic activity, sedation and weakness. While trazodone is not a true member of the SSRI class of antidepressants, it does still share many properties of the SSRIs, especially the possibility of discontinuation syndrome if the medication is stopped too quickly.
Commonly Prescribed Psychotropic Medications
Common side effects of antipsychotics include sedation, anticholinergic effects, orthostatic hypotension, extrapyramidal symptoms and tardive dyskinesia. DrugPoint System Internet [cited Oct 1]. Elevated prolactin concentrations have been observed in patients taking trazodone. Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramineetc.
Alprazolam as an alternative to low-dose haloperidol in older, cognitively impaired nursing facility patients. The updated HCFA regulations change some antipsychotic dosing restrictions.