Clomiphene failure definition

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Guzick DS, Zeleznik A. However, this requires that sperm survival in the upper genital tract is two or more days and, in some instances, this may not be the case. The participants were allowed to pursue natural sexual life and no intervention like intra uterine insemination was done.

Clomiphene citrate use for ovulation induction: When, why, and how?

Brain activation differs in women with HSDD and those with normal sexual function https: How should clomiphene citrate be used? If the patient does not ovulate at a maximum clomiphene citrate dosage of mg daily, alternative approaches to ovulation induction should be considered because the incremental ovulatory rate for dosages higher than mg daily for 5 days is minimal. New York, New York: Selective estrogen receptor modulators: Ovulation induction management of PCOS.

Recently, some reports discussed the possible beneficial effects of NAC on ovulation. Immune problems may range from antisperm antibodies to outright rejection of a developing fetus. How does clomiphene citrate induce ovulation? Please enable your JavaScript to continue use our site.


By definition, women with oligomenorrhea can have ovulatory cycles, albeit infrequently. Diet and health Beyond the Basics. Study by Youssef et al. Consensus on infertility treatment related to polycystic ovary syndrome.

The mechanism of tamoxifen in improving folliculogenesis may involve a direct action on the ovary without intervention of hypothalamo-pituitary system as suggested in the studies by Fukushima et al. Nine conceived with 40 mg dosage and 11 became pregnant with 80 mg of tamoxifen.

Inresearchers reported that in women with PCOS, the use of letrozole to induce ovulation resulted in higher live birth rates eg, more women became pregnant and carried to term than clomiphene [ 4 ].

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Over a 3-month follow-up period, women in metformin-CC group had significantly higher ovulation and pregnancy rates compared with women in NAC-CC group As previously discussed, antiestrogenic effects of clomiphene cit-rate in the endometrium and endocervix may interfere with sperm survival and transport and may affect implantation.

However, it has been questioned as a cause of infertility because fertile women are commonly found to have out-of-phase endometrium.

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Although no studies directly compare clomiphene citrate alone with clomiphene citrate and IUI, combined retrospective analysis of studies by Guzick et al 33 estimates a 5. Clomiphene citrate resistance in relation to follicle-stimulating hormone receptor SerSer-polymorphism in polycystic ovary syndrome. However, pregnancy rates with this drug are not as good as ovulation rates.