Valsartan hct novartis

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Store in the original package in order to protect from moisture. If hypotension occurs, the patient should be placed in the supine position and salt and volume supplementation should be given rapidly.

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The clinical significance of this effect is uncertain and not sufficient to preclude their use. The following adverse reactions have been reported in patients treated with monotherapy of thiazide diuretics, including hydrochlorothiazide: In each case, up-titration of individual components to the next dose should be followed in order to reduce the risk of hypotension and other adverse events.

Administration of valsartan to patients with hypertension results in reduction of blood pressure without affecting pulse rate. Beneficial effects of valsartan in combination with hydrochlorothiazide on cardiovascular mortality and morbidity are currently unknown.

Angioedema, dermatitis bullous, rash, pruritus.

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Older people No dose adjustment is required in elderly patients. When clinically appropriate direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorothiazide monotherapy, provided the recommended dose titration sequence for the individual components is followed. Hydrochlorothiazide crosses the placenta.


Minimal decreases in plasma aldosterone were observed after administration of valsartan; very little effect on serum potassium was observed. Valsartan shows bi-exponential decay kinetics following intravenous administration, with an average elimination half-life of about 6 hours.

As with all other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or hypertrophic obstructive cardiomyopathy HOCM. Ion exchange resins Absorption of thiazide diuretics, including hydrochlorothiazide, is decreased by cholestyramine or colestipol.

Not all pack sizes may be marketed. Before calling a member of our support team, please attempt to regenerate your report again from your purchase history page. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so Diovan HCT is not recommended.

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Body as a Whole: Hydrochlorothiazide is excreted in human milk. The antihypertensive effect is independent of age or gender.

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This reduction in AUC is not, however, accompanied by a clinically significant reduction in the therapeutic effect, and valsartan can therefore be given either with or without food.

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However, these studies have been conducted for valsartan as well as hydrochlorothiazide alone. In long-term follow-up studies without placebo control the effect of valsartan appeared to be maintained for up to two years.

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Please click the following link to register and submit an upgrade request, so that a member of our sales team can contact you to discuss your requirements. Its action is therefore independent of the pathways for angiotensin II synthesis.

Untreated acute-angle closure glaucoma can lead to permanent vision loss. Dose Titration by Clinical Effect: