Comparison of pravastatin and simvastatin

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The safety, tolerability, and efficacy of 20 mg daily doses of simvastatin and pravastatin were compared in this double-blind, randomized trial of patients with primary hypercholesterolemia. Muscle pain and kidney damage. Am J Med ; Simplified flow chart of major considerations for statin selection or substitution. If creatinine clearance is less than 60 mL per minute 1.

Clinically relevant differences between the statins: Available for Android and iOS devices. What's the difference between provastatin and simvastatin?

Head-to-head comparisons of medication uses, side effects, ratings, and more.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. See My Options close. When comparing individual statins, simvastatin and pravastatin appeared to have the best safety profiles, and because of that they "should be favored in clinical practice," the investigators reported online in Circulation: A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference.

View latest questions Search for answers Ask a question. Still looking for answers? In a meta-analysis of trials comparing the statins versus placebo, there were no differences in rates of discontinuation because of adverse events OR 0. This website uses cookies to deliver its services as described in our Cookie Policy.

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Generate a file for use with external citation management software. Rituxan Has Promise in Idiopathic Nephropathy. However, in patients who do not achieve their LDL goals, atorvastatin and simvastatin may be the best choices for initial therapy. Zocor simvastatin is a good medication to improve your cholesterol.

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Can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking. Sign In or Register.

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The study included information from randomized trials -- 55 with a placebo control and 80 with an active comparator -- that included a total ofparticipants with or without cardiovascular disease.

Skip to Content googletag. If you have liver problems, Pravachol pravastatin is the safest statin to use. Expert Perspective Follow experts from across more than 30 medical specialties who share their viewpoints and guidance on medical developments as they unfold.

What is the difference in pravastatin 20mg and simvastatin 80 mg? All statins are associated with drug interactions, mainly because of their effects on the cytochrome P enzymatic pathway.