Small decreases in blood pressure have been observed in some patients treated with pentoxifylline; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensives. Moderate Concomitant administration of dexmedetomidine and calcium-channel blockers could lead to additive hypotension and bradycardia; use together with caution.
If you don't take it on schedule: One report suggests that concentrations in breast milk may approximate serum levels.
How does this medication work? What will it do for me?
Moderate The combination of diltiazem and a beta-blocker, like acebutolol, is usually well tolerated; the combination is often used for their combined therapeutic benefits to reduce angina and improve exercise tolerance. Moderate Prednisone is metabolized by the liver to the active metabolite prednisolone. No data are available regarding coadministration of efavirenz with other calcium channel blockers that are CYP3A4 substrates e.
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Monitor blood pressure and fluid volume status closely in patients receiving conivaptan infusion. Swallow whole; do not split, crush, or chew the tablets; per the labeled instructions to patients, the medication is formulated to slowly release.
This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. If treatment with diltiazem is unavoidable, lomitapide should be stopped during the course of treatment. Swelling of the legs can add weight to the body. Major Monitor for an increased incidence of etoposide-related adverse effects if used concomitantly with diltiazem. Cartia XT mg, orange, capsule.
Moderate Concomitant administration of bradycardia-inducing drugs e. Due to its inhibitory effects on AV node conduction, diltiazem is contraindicated in patients with preexisting second- or third-degree AV block or previous conduction abnormalities.
The interaction between verapamil and lithium is variable and unpredictable. Dihydroergotamine is contraindicated for use in patients with coronary heart disease or hypertension. Periodic evaluation of blood pressure is advisable during concurrent use of methylphenidate and antihypertensive agents, particularly during initial coadministration and after dosage increases of methylphenidate.
One case of a possible verapamil-clarithromycin interaction was reported, which was associated with hypotension. The manufacturer reports that about 1 to 3 percent of patients are affected. Moderate Caution is advised when administering tenofovir, PMPA, a P-glycoprotein P-gp substrate, concurrently with inhibitors of P-gp, such as diltiazem.
This medication can slow down the removal of other medications from your body, which may affect how they work. Diltiazem ER is the extended release formulation of diltiazem HCl and is designed to release the medication slowly into the body.
As diltiazem is both a substrate and an inhibitor of CYP3A4, monitor patients for corticosteroid-related side effects if prednisone and diltiazem are taken.