Caution is needed with ciclosporin, erythromycin, and clarithromycin.
If you experience unexplained muscle pain, tenderness, weakness, or discoloration of urine, contact your healthcare professional e. Significant Potential for significant interaction monitoring by your doctor is likely required. Older people taking statins for high cholesterol should avoid taking the antibiotics clarithromycin or erythromycin at the same time because of potential kidney injury from an interaction, Canadian doctors say.
This material does not endorse drugs, diagnose patients, or recommend therapy. Causes, diagnosis, and treatment.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Patients taking digoxin should be monitored appropriately. Maintenance doses The table below gives important dose restrictions for atorvastatin and simvastatin when used in combination with other drugs.
Patients in both groups were well matched for demographics, comorbidities, statin dose, and concurrent medications. Summary and Recommendations The risk of a serious adverse event caused by the co-administration of erythromycin or clarithromycin with statins that are substrates for CYP3A4 is small but the potential severity is great enough that an attempt should be made to avoid the interaction. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Nursing mothers It is not known whether atorvastatin is excreted into human milk; however a small amount of another drug in this class does pass into breast milk.
Professionally-verified articles Daily or weekly updates Content custom-tailored to your needs Create an account. Letter sent to healthcare professionals for atorvastatin in December Letter sent to healthcare professionals for atorvastatin in December Features and specialized departments cover medication errors, drug interactions, patient education, pharmacy technology, disease state management, patient counseling, product news, pharmacy law and health-system pharmacy.
In addition, many antiviral agents inhibit CYP3A4, including amprenavir Ageneraseatazanavir Reyatazdarunavir Prezistafosamprenavir Lexivaindinavir Crixivannelfinavir Viraceptritonavir Norvirsaquinavir Inviraseboceprevir Victrelistelaprevir Incivekand tipranavir Aptivus. Rhabdomyolysis occurs when the body can't metabolize proteins released from the muscles and they enter the bloodstream. Patients and Caregivers Clinician Explanation. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.
Register for a free account Sign up for a free Medical News Today account to customize your medical and health news experiences. Statins are frequently prescribed with antibiotics.
Available for Android and iOS devices. The common antibiotic clarithromycin is frequently prescribed alongside statins. Contents Simvastatin and atorvastatin: