Ketoconazole gel preparation

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This is only a brief summary of general information about ketoconazole gel. Sonication is one of the most popular methods used for producing a lipid vesicle of known size.

Amount of entrapped drug was obtained by subtracting amounts of un-entrapped drug from the total drug incorporated. The increase in the entrapment efficiency is attributed to the ability of CHO to cement the leaking space in the bilayer membranes, which in turn allow enhanced drug level in niosomes.

The incorporation of ketoconazole in an adapted vehicle further promoted its efficacy.

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These are not all of the side effects that may occur. Development of naftifine hydrochloride alcohol-free niosome gel. For the characterization of the release kinetics, the in vitro drug release data was fitted to First order plots, Higuchi diffusion plots and Peppas log-log plots [ Figure 3 ].

So after considering all these parameters, formulation TNS 4 was found to be the best having vesicle size of 5. You must talk with the healthcare provider for complete information about the risks and benefits of using ketoconazole gel.

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A dialysis membrane soaked in distilled water 24 h before use is fixed to the one end of the cylinder with the aid of an adhesive. In the past few decades, considerable attention has been focused on the development of a new drug delivery system.

The content was filtered through Whatman filter paper No.

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A development of system which controls the release and enhances the bioavailability of Ketoconazole, an fungal activity is in demand. Trake Your Article Trake your article. Niosomal gel Carbopol was chosen to prepare the niosomal gel in this study, which is due to its hydrophilic nature and bioadhesive properties, which may result in an increased residence time of a drug at the site of absorption by interacting with the mucosa.

At every hour, entire medium ml was replaced with fresh medium for about h until the absorbance reached a constant reading indicating no drug is available in an un-entrapped form.

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Please review our privacy policy. Different types of pharmaceutical carriers, e. Rheological study Viscosity measurement: Several antifungal agents are available in the market in different topical preparations e.


Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information should not be used to decide whether or not to take this medicine or any other medicine.

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Results indicate that F exhibits maximum antifungal activity after 24 h. Tinea Corporis clotrimazole topicalketoconazole topicalLotrisoneterbinafine topicalLamisilMore