This includes prescription or nonprescription over-the-counter [OTC] medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements. However, both were shown to induce chromosomal aberrations in cultured cells in vitro Chinese hamster lung and both tested positive for thymidine kinase mutations in the in vitro mouse lymphoma assay. Side effects in more detail.
Dosing & Uses
Other adverse reactions that have been reported with an incidence of greater than 1. Staggering the dosage of hydrochlorothiazide and ion exchange resins e. This medication is not recommended for use during pregnancy due to the risk for harm to an unborn baby.
Do not start, stop, or change the dosage of any medicines without your doctor's approval. It is unknown if olmesartan passes into breast milk.
Using this medicine while you are pregnant can harm your unborn baby. It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example, patients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
Blood Pressure Topics
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Do not take other medicines unless they have been discussed with your doctor. Medications can interact with certain foods. The mechanism of the antihypertensive effect of thiazides is not fully understood. By clicking send, you acknowledge that you have permission to email the recipient with this information.
There are, however, concerns with the credibility of the finding of increased CV risk, notably the observation in the large epidemiologic study for a survival benefit in non-diabetics of a magnitude similar to the adverse finding in diabetics. Side Effects Dizziness or lightheadedness may occur as your body adjusts to the medication. Need help identifying pills and medications? Drugs that inhibit the RAS can cause hyperkalemia.
Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. Tell you doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Concomitant aliskiren in patients with diabetes. Some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients, and many antihypertensive drugs have additional approved indications and effects e.
If it continues for a long time, the heart and arteries may not function properly.