Based on prospective reports to the APR of over 13, exposures to zidovudine during pregnancy resulting in live births including over 4, exposed in the first trimesterthere was no difference between the overall risk of birth defects for zidovudine compared with the background birth defect rate of 2.
Beware of Diabetes Foot Dangers. May increase the hematologic toxicity of zidovudine. Combivir is used, in combination with other agents, for the treatment of HIV infection. This medicine may cause muscle aches and stiffness if it is used for long periods of time. Clinical and laboratory evidence of exacerbations of hepatitis have occurred after discontinuation of lamivudine.
Lamivudine / Zidovudine
Avoid being near people who are sick or have infections. Tell your doctor if you are pregnant or plan to become pregnant.
Zidovudine mg every 4 h x 7 days. Dose reduction or discontinuation of interferon alfa, ribavirin, or both should also be considered if worsening clinical toxicities are observed, including hepatic decompensation e.
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Am I Having a Heart Attack? This is a drug discount program, not an insurance plan. Nervous Paresthesia, peripheral neuropathy, seizures. Print this page Add to My Med List. Combivir may cause a serious condition called lactic acidosis. Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this drug.
Your blood will need to be tested often. Perhaps a survey of patients, providers, payors, and other interested parties found little appetite for breaking these combinations up, which is what would be required to get generic 3TC prescribed.
Zidovudine is eliminated primarily by hepatic metabolism.
Use of Combivir during pregnancy has not been adequately evaluated. Migraine Triggers You Can Avoid.
Not all possible interactions are listed in this medication guide. Suddenly, AZT was fine. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected. The other brands listed are trademarks of their respective owners and are not trademarks of the ViiV Healthcare group of companies.
Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including lamivudine, zidovudine, and other antiretrovirals.
The makers of branded HIV drugs have made an elaborate deal with the generic companies involving the transfer of huge sums of cash preferably to an off-shore bank account in exchange for not making generic 3TC. Lamivudine The chemical name of lamivudine is 2R,cis amino 2-hydroxymethyl-1,3-oxathiolanyl - 1H -pyrimidinone. Prescription is for a pet. We comply with the HONcode standard for trustworthy health information - verify here.