Mitotane is a strong CYP3A4 inducer and atorvastatin is a CYP3A4 substrate; coadministration may result in decreased plasma concentrations of atorvastatin.
The incidence of nonfatal hemorrhagic stroke was significantly higher in the atorvastatin group 1. Moderate Caution is advised when administering voxilaprevir with atorvastatin. Delavirdine is a potent inhibitor of CYP3A4. Major Measure serum digoxin concentrations before initiating atorvastatin.
These are vital nursing interventions done in patients who are taking cholesterol absorption inhibitors:. Atorvastatin should be used with caution in organ transplant and other patients receiving immunosuppressant therapy such as cyclosporine because of an increased risk of rhabdomyolysis and renal failure; lower initial and maximum doses of atorvastatin are recommended for such patients.
Patients should be monitored for therapeutic effectiveness when clopidogrel is administered with atorvastatin. Crizotinib inhibits P-gp at clinically relevant concentrations and has the potential to increase plasma concentrations of drugs that are substrates of P-gp. The effects of statins on spermatogenesis and fertility have not been studied in adequate numbers of patients.
Clarithromycin inhibits the CYP3A4 metabolism of atorvastatin.
It can result to breakdown of muscles. Moderate Lumacaftor; ivacaftor may alter the systemic exposure of atorvastatin; if used together, monitor serum lipid concentrations. Rhabdomyolysis has been reported during concurrent use of atorvastatin and telithromycin. Atorvastatin is a CYP3A4 substrate; therefore, quinine has the potential to inhibit the metabolism of atorvastatin leading to an increased potential of rhabdomyolysis.
Moderate Monitor for potential reduced cholesterol lowering efficacy when barbiturates are coadministered with atorvastatin.
The AUC of atorvastatin was unchanged. A patient who is taking a bile acid sequestrant complains of abdominal distention and nausea. Monitor serum lipid profile and for signs and symptoms of myopathy during coadministration.
All of the following are factors of CAD, except:. Untreated bacterial infections can also contribute to CAD. Coadministration of atorvastatin 40 mg with diltiazem mg was associated with a higher plasma concentration of atorvastatin. Atorvastatin is a substrate of CYP3A4. Moderate Caution is advised with the concomitant use of sapropterin and atorvastatin as coadministration may result in increased systemic exposure of atorvastatin.
Fosaprepitant mg IV as a single dose increased the AUC of midazolam given on days 1 and 4 by approximately 1.
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Prepare emergency equipment at bedside. Waste products from this muscle breakdown injure glomeruli and can lead to acute renal failure. Paul Martin, RN - Nov 9, 0. Moderate The risk of myopathy and rhabdomyolysis is increased by concomitant administration of danazol with atorvastatin.
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