Bioavailability following IV administration varies; there is considerable interindividual variation in plasma chloramphenicol concentrations. In vitro, chloramphenicol exerts mainly a bacteriostatic effect on a wide range of gram-negative and gram-positive bacteria. The following method of administration is recommended: Administration of chloramphenicol concomitantly with bone marrow depressant drugs is contraindicated, although concerns over aplastic anaemia associated with ocular chloramphenicol have largely been discounted.
J Pak Med Assoc.
These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. In instances of impaired metabolic processes, dosages should be adjusted accordingly. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick.
Discontinue chloramphenicol if reticulocytopenia, leukopenia, thrombocytopenia, anemia, or any other blood study findings attributable to the drug occur. Gray syndrome can be fatal within a few hours of symptom onset; symptoms include abdominal distension with or without emesisprogressive pallid cyanosis, and vasomotor collapse frequently accompanied by irregular respiration. It was first used to treat meningitis in  and numerous studies since have demonstrated its efficacy.
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Effect of rifampin on chloramphenicol levels. The drug should be discontinued upon appearance of reticulocytopenia, leukopenia, thrombocytopenia, anemia or any other blood study findings attributable to chloramphenicol. The Journal of Biological Chemistry. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Excessive chloramphenicol concentrations may occur in patients with impaired renal function. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of the drug can be used. Home Drug Databases Drug Shortages. No studies have been conducted in animals or humans to evaluate the possibility of these effects with chloramphenicol.
Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations MICs. Clinical features of Pseudomonas cepacia pneumonia in an epidemic among immunocompromised patients. Accessed November 08, What are the side-effects of Chloramphenicol Sodium Succinate Injection? In other projects Wikimedia Commons. Some strains of E.
Optic and peripheral neuritis reported, usually following long-term therapy. Asparaginase Erwinia Chrysanthemi Erwinaze. It is not known whether monitoring the blood counts of patients can prevent the development of aplastic anaemia, but patients are recommended to have a baseline blood count with a repeat blood count every few days while on treatment.