Conversion to oral therapy with intravenous ciprofloxacin plus metronidazole appeared as effective as continued intravenous therapy in patients able to tolerate oral feedings.
Other uses of switch therapy can include the treatment of spontaneous bacterial peritonitis. InAdler et al conducted a randomized, double-blinded, placebo-controlled study on doxepin to evaluate the effect of a switch from parenteral to oral administration upon symptoms of endogenous depression. Ciprofloxacin also has a role in IV-to-PO switch therapy. Specifically, Van den Brande and colleagues noted that intravenous cefuroxime twice daily followed by oral cefuroxime axetil is a simple and effective sequential therapy regimen for the treatment of CAP.
The oral bioavailability is Strategies for early discharge of the hospitalized patient with community-acquired pneumonia.
Antibiotic therapy of hospitalized patients with community-acquired pneumonia: All fluoroquinolones have excellent bioavailability except Norfloxacinso use PO whenever possible. Outcomes of early switching from intravenous to oral antibiotics on medical wards. While intravenous medications may be more bioavailable and have greater effects, some oral drugs produce serum levels comparable to those of the parenteral form.
Effects are associated with a decrease in symptoms of depression. InLi et al noted that intravenous linezolid can be followed by oral linezolid; these regimens were found to shorten hospital stays. Intravenous-to-oral antibiotic switch therapy. Cefotetan can cause elevated INR. InGollin et al reported on a study of 80 children who underwent appendectomy for perforated appendicitis.
The time to resolution of fever was also statistically significantly faster in patients who received moxifloxacin median time, 2 vs 3 dand the duration of hospital admission was approximately 1 day less among patients who received moxifloxacin.
Cefoxitin, Cefotetan — beware increasing resistance of Bacteroides Cefoxitin is better than Cefotetan, but avoid both for serious intraabdominal infections. Virtually no Gram positive or anaerobic coverage.
Also used for STD Chlamydia. InWawruch et al reported on an evaluation of a group of patients selected out of patients who were hospitalized at the Clinic of Geriatric Medicine at Comenius University in Bratislava from January 1,to December 31, Janknegt R, van der Meer JW.
Int J Infect Dis. An already-low plasma level during the infusion period, insufficient response, and questionable compliance with the oral medication were associated factors. Caspofungin First approved echinocandin. Cefotaxime is more frequent dosing often used preferentially for spontaneous bacterial peritonitis due to good track record and high levels achieved in ascitic fluid, but Ceftriaxone probably equivalent.