Shelf life lamotrigine

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Not all pack sizes may be marketed. Lamotrigine Tablets should be swallowed whole with a little water and should not be chewed or crushed. Peak plasma concentrations occur approximately 2.

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Patients and caregivers of patients should be advised to seek medical advice should signs of suicidal ideation or behaviour emerge. In clinical trials, there was no increase in the incidence, severity or type of adverse reactions following abrupt termination of lamotrigine versus placebo.

Risk related to lamotrigine Pregnancy A large amount of data on pregnant women exposed to lamotrigine monotherapy during the first trimester of pregnancy more than do not suggest a substantial increase in the risk for major congenital malformations, including oral clefts.

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In women not already taking an inducer of lamotrigine glucuronidation and taking a hormonal contraceptive that includes one week of inactive treatment for example "pill-free week"gradual transient increases in lamotrigine levels will occur during the week of inactive treatment see section 4.

Adults aged 18 years and above - maintenance stabilisation total daily dose following withdrawal of concomitant medicinal products in treatment of bipolar disorder Once the target daily maintenance stabilisation dose has been achieved, other medicinal products may be withdrawn as shown below.

Posts related to self harm will be removed immediately and the poster will be banned. Children and adolescents below 18 years Lamotrigine Tablets is not recommended for use in children below 18 years of age due to a lack of data on safety and efficacy see section 4.

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When concomitant antiepileptic drugs AEDs are withdrawn to achieve lamotrigine monotherapy or other antiepileptic drugs AEDs are added on to lamotrigine monotherapy consideration should be given to the effect this may have on lamotrigine pharmacokinetics see section 4. Withdrawal of medicinal products that do NOT significantly inhibit or induce lamotrigine glucuronidation see section 4. Each Lamictal mg tablet contains mg lamotrigine. Dose-related adverse events cannot be excluded.

Lamotrigine has a slight inhibitory effect on dihydrofolic acid reductase and could therefore theoretically lead to an increased risk of embryo foetal damage by reducing folic acid levels see section 4.

If such signs and symptoms are present the patient should be evaluated immediately and lamotrigine discontinued if an alternative aetiology cannot be established. Infants aged 2 to 26 months. There are no data in children below 1 month of age.

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Excipient of Lamotrigine tablets. Find medicines from the same company. Date of first authorisation: Therefore lamotrigine serum concentrations should be monitored before, during and after pregnancy, as well as shortly after birth.

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Potential interactions between levetiracetam and lamotrigine were assessed by evaluating serum concentrations of both agents during placebo-controlled clinical trials. General disorders and administration site conditions During bipolar disorder clinical trials: Effects of other medicinal products on glucuronidation of lamotrigine. Each tablet contains 25mg Lamotrigine.

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Restarting therapy Prescribers should assess the need for escalation to maintenance dose when restarting Lamictal in patients who have discontinued Lamictal for any reason, since the risk of serious rash is associated with high initial doses and exceeding the recommended dose escalation for lamotrigine see section 4.