CS1 German-language sources de Webarchive template wayback links Template: Retrieved 14 December Archived from the original on June 3, In Marchthe U. Clopidogrel generally has a low potential to interact with other pharmaceutical drugs.
Patients with a variant allele of CYP2C19 are 1. Only one of the eight structures is an active antiplatelet drug.
Consensus-based therapeutic guidelines also recommend the use of clopidogrel rather than ASA for antiplatelet therapy in people with a history of gastric ulceration, as inhibition of the synthesis of prostaglandins by ASA can exacerbate this condition.
The New England Journal of Medicine.
This page was last edited on 5 Novemberat In this trial the following rates of bleeding were observed.
BMJ Clinical research ed. Focus Update on Prasugrel". Ingeneric clopidogrel was briefly marketed by Apotexa Canadian generic pharmaceutical company before a court order halted further production until resolution of a patent infringement case brought by Bristol-Myers Squibb. In people with healed ASA-induced ulcers, however, those receiving ASA plus the proton pump inhibitor esomeprazole had a lower incidence of recurrent ulcer bleeding than those receiving clopidogrel. Archived PDF from the original on Clopidogrel has also been shown to be effective at decreasing platelet aggregation in cats, so its use in prevention of feline aortic thromboembolism has been advocated.
Antithrombotics thrombolyticsanticoagulants and antiplatelet drugs B B No risk in non-human studies. Reduced effectiveness of Plavix clopidogrel in patients who are poor metabolizers of the drug".